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Which observation would most seriously challenge the hypothesis that most noncoding DNA is slightly deleterious?

- Species with smaller population sizes have more noncoding DNA.
- Species with larger genomes lose DNA more quickly through mutational processes than those with smaller genomes.
- There is an inverse relationship between the total amount of DNA in the genome and the percentage of the DNA that is noncoding.
- Species with larger population sizes have more noncoding DNA.
- Species with larger genomes lose DNA more slowly through mutational processes than those with larger genomes.