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The information in pedigrees that is useful for mapping disease genes is sometimes limited. This pedigree shows segregation of neurofibromatosis, which is a fully-penetrant, autosomal dominant condition, and a single nucleotide polymorphism, SNP1, which has alleles G or T. Why is the cross in generation I not useful for determining the degree of linkage between the disease-causing gene NF and SNP1?

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luisvaschetto

Answer:

Since neurofibromatosis is an autosomal dominant condition, the cross between individuals with genotypes carrying the same SNP type is not useful to show the degree of linkage between the disease-causing gene NF and SNP1. This occurs because it is necessary to observe segregation for the trait in order to determine its effects