Identify the correct statements about Lesch-Nyhan syndrome.

There is more than one correct statement. Check all the true statements.

a. Uric acid is produced in excess with this syndrome, and in excess it acts as a prooxidant.

b. Gout causes Lesch-Nyhan syndrome.

c. Some symptoms of Lesch-Nyhan syndrome include involuntary movements and self-mutilation.

d. This syndrome is caused by a deficiency in 5-phospho-D-ribosyl-1-pyrophosphate (PRPP).

e. This deficiency does not allow purine nucleotide production via the salvage pathway.

Lesch Nyhan syndrome is characterized by behavioral and neurological abnormalities, and excess uric acid production in the body. It occurs in males, almost exclusively.

Changes (mutations) in the HPRT1 gene causes Lesch Nyhan syndrome and is inherited in a recessive X-linked way. Several symptoms of Lesch Nyhan syndrome are Inflammatory arthritis (gout), involuntary movements, self-injury and kidney stones.

Hence, the correct option are a. and c.